Companion Algorithms™
Brain Cancer
Common adult tumors of the brain include meningioma, astrocytomas and oligodendroglioma. Specifically, astrocytic tumors include pilocytic astrocytoma (grade I), diffuse astrocytoma (WHO grade 2), anaplastic astrocytoma (WHO grade 3) and glioblastoma (WHO grade 4). Accurate differentiation is important as grade is a predictor of survival. Methods currently used for grade assignment include mitotic counts, evidence of necrosis, and microvascular proliferation¹. Recent studies have also suggested that immunohistochemistry with the cellular proliferation marker, Ki-67 is useful in the determination between grades 2 and 3 or 4². BioImagene's Ki67 brain algorithm* detects and counts Ki-67 labeled glial tumor cells in brain cancer samples.
1. Miller CR, et al. Arch Pathol Lab Med 2007 131(3):397-406
2. Torp SH Clin Neuropathol 2002 21(6):252-257
*BioImagene products are FDA cleared for specific clinical applications and are intended for research use for other applications.
